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KMID : 0617319950050010160
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Journal of Pharmacetical Sceiences Ewha Womans University
1995 Volume.5 No. 1 p.160 ~ p.161
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The Stereochemical Outcome of the DAST Fluorination of 4´-Thiopyrimidine Nucleosides with "Up" Hydroxyl Groups is Controlled by the Oxidation State of the Sulfur Atom
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Jeong Lak-S.
Victor E. Marquez
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Abstract
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DAST fluorination of 1-(5-O-trityl-3-deoxy-4-thio-β-D-threo-pentofuranosyl)uracil proceeds with retention of configuration, while the corresponding sulfoxide gives mainly the inverted product. The sulfone proceeds with elimination.
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